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August 30, 2009

Fat-fighting pill that reverses diabetes while lowering cholesterol?

Topics: Health Issues

Is it possible that a pill to fight fat that reverses diabetes and lowers cholesterol at the same time be in the works? Possibly. But don't give up your diet, just yet.

According to Newsmax Health, researchers searching for a cure for obesity have developed a drug that not only makes mice lose weight, but reverses diabetes and lowers their cholesterol, too. The drug, dubbed fatostatin, apparently stops the body from making fat, instead releasing the energy from food. They hope it may lead to a pill that would fight obesity, diabetes and cholesterol, all at once:

Writing in the journal Chemistry and Biology, Salih Wakil of Baylor College of Medicine in Texas, Motonari Uesugi of Kyoto University in Japan and colleagues said the drug interferes with a suite of genes turned on by overeating.

"Here, we are tackling the basics," Wakil said in a telephone interview. "I think that is what excited us."

Scientists are painfully aware that drugs that can make mice thin do nothing of the sort in humans. A hormone called leptin can make rats and mice drop weight almost miraculously but does little or nothing for an obese person, for instance.

But Wakil, whose team has patented the drug and is looking for a drug company to partner with, hopes this drug may be different. "I am very, very optimistic," he said.

Fatostatin is a small molecule, meaning it has the potential to be absorbed in pill form.

Posted by Richard at August 30, 2009 7:45 PM

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