December 29, 2005
High Antioxidant Diet May Delay Age-Related Macular DegenerationTopics: Medicine
Age-related macular degeneration (AMD) is the most prevalent cause of irreversible blindness in developed countries. It is the most common cause of vision loss in the United States in those 50 or older, and its prevalence increases with age. AMD is caused by hardening of the arteries that nourish the retina. This deprives the sensitive retinal tissue of oxygen and nutrients that it needs to function and thrive. As a result, the central vision deteriorates.
However, a study published in the Dec. 28 issue of the Journal of the American Medical Association, suggests that a diet high in antioxidants, including vitamins C and E, may forestall age-related macular degeneration.
According to researchers that conducted the study, older individuals who consumed above-median amounts of beta carotene, zinc, and vitamins C and E in their diet were 35% less likely to be diagnosed with the disease.
There is evidence that antioxidant supplements can be beneficial. The randomized, placebo-controlled Age-Related Eye Disease Study (AREDS) showed that supplement intake of five to 13 times the recommended daily allowance (RDA) of beta carotene, vitamins C and E, and zinc, given to participants from retinal clinics with early or monocular late AMD, resulted in a 25% reduction in the five-year progression to late age-related macular degenerationIn the study, dietary intake of both vitamin E and zinc was inversely associated with incident AMD, with a hazard ratio (HR) per standard deviation increase of intake for vitamin E of 0.92 (95% confidence interval [CI], 0.84-1.00). For zinc the HR was 0.91 (95% CI, 0.83-0.98). An above-median intake of all 4 nutrients, beta carotene, vitamin C, vitamin E, and zinc, was associated with a 35% reduced risk (HR, 0.65; 95% CI, 0.46-0.92) of AMD, and exclusion of supplement users did not affect the results.
It's important to keep in mind that the data needs to be confirmed by a prospective trial designed to evaluate the specific effects of these compounds before definitive recommendations can be made.
Antioxidant supplements prevent oxidation of cysteine/cystine redox in patients with age-related macular degeneration
Posted by Richard at December 29, 2005 10:13 PM
Thank you for this information. I will definitely be sharing it with friends and family as well as clients.
Posted by: Sandstorm at January 1, 2006 2:33 PM
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