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November 1, 2005

Vitamin D Could Play a Role in Preventing Prostate Cancer

Topics: Medicine
A recent study suggests that Vitamin D (active metabolite - calcitriol), may be useful in preventing prostate cancer.
calcitriol-1.gif

Calcitriol has been used clinically to treat a variety of disorders, including, in recent clinical trials, cancer. However, an obstacle to its clinical use has been dose-limiting hypercalcemia, an abnormally high concentration of calcium in the blood. Now, The active metabolite of vitamin D - calcitriol, and two Vitamin D analogs, QW-1624-F2-2 (QW), developed at John's Hopkins University, and paricalcitol - have been shown to be less calcemic, enabling their application for clinical use.

Importantly, QW and paricalcitol have been shown to reduce the level of parathyroid hormones, which regulate the metabolism of calcium and phosphorus in the body, and in in-vitro (test tube or culture dish) studies, the three drugs (calcitriol, QW, and paricalcitol) inhibited cell growth, inhibited DNA synthesis, and promoted cell cycle arrest.

In in-vivo (inside the body) studies (mouse model) to determine the effects of calcitriol and the analogs on the prevention of prostate cancer, the researchers found evidence that the active metabolite of vitamin D, calcitriol, and two other vitamin D analogs (QW-1624-F2-2 and paricalcitol) may be promising chemopreventive agents for prostate cancer treatment.

Posted by Richard at November 1, 2005 9:33 PM



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