September 2, 2005
Omega-6 fatty acids cause prostate tumor cell growth in cultureTopics: Medicine
I've previously posted on two omega-3 fatty acids, docosahexaenoic acid(DHA) and eicosapentaenoic acid(EPA) found in fish, and how in combination with a commonly used anaesthetic, Propofol, they may form the basis for effective new drugs to treat breast cancer. I've also posted that according to an article in the June 21, 2005, issue of the Journal of the American College of Cardiology, older people who ate fish once or twice a week had a 20 percent lower risk of developing congestive heart failure during 12 years of follow-up. These benefits, and others, seem to be connected with the amount of omega-3 fatty acids the study participant consumed. Those with the highest levels of intake had a 37 percent lower risk of congestive failure than those with the lowest intake of omega-3 fatty acids. If you haven't yet got the message, omega-3 fatty acids are very important fats.
Now we're hearing that omega-6 fatty acids can cause tumor cell growth in-vitro, and that 60 years ago in the United States, the dietary ratio of omega-6 to omega-3, a very beneficial fatty acid, was 1 to 2. Today, the ratio is 25 to 1. Over that same 60 years, the incidence of prostate cancer in the U.S. has increased steadily.
(...) The Indiana team studied the effect of two omega-3 fatty acids - docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA).Phospholipase A2 (cPLA2) is a cytosolic enzyme (enzyme found in the internal fluid of the cell) responsible for the release of arachidonic acid from the phospholipids membrane of cells. The expression of cPLA2 not only exerts an oncogenic activity in prostate cancer, but is also increased in such cancers as colorectal, small bowel, and lung cancer. It's entirely feasable that omega-6 fatty acid causes the production of cPLA2, as suggested by the article, which induces the production of cPLA2. But it's more likely that it's not only dietary intake of omega-6 fatty acid that is the culprit, rather intake AND the RATIO of omega-6 to omega-3 fatty acids. With this in mind you should limit your intake of omega-6 fatty acids while increasing your intake of omega-3 fatty acids. If you're not eating several servings of cold water fish high in omega-3 fats, try taking a couple of teaspoons of "Carlson's Finest Fish Oil - liquid" every day, or at least a few times a week. Unless you can afford pharmaceutical grade fish oil, Carlson's is the only brand I'd recommend (I have no stock in the company).
(...) omega-6 fatty acids such as the fat found in corn oil promote the growth of prostate tumor cells in the laboratory.
(...) The study also identifies a potential new molecular target for anti-tumor drugs: an enzyme known as cPLA2, which plays a key role in the chain leading from omega-6 fatty acids to prostate tumor cell growth.
(...) When introduced into prostate tumor cells in culture, omega-6 fatty acid causes the production of cPLA2, which then causes the production of the enzyme COX2. In turn, COX2 stimulates the release of PGE2, a hormone-like molecule that promotes cell growth.
(...) "What's important about this is that omega-6 fatty acids are found in corn oil and most of the oils used in bakery goods,"
(...) "Which means that if you're eating a diet high in omega-6 fatty acids, it's possible that you're turning on this cancer cascade, which has been shown to be a common denominator in the growth of prostate, colorectal, and some breast cancers."
(...) flurbiprofen, a non-steroidal anti-inflammatory drug commonly prescribed for arthritis, blocked the production of cPLA2 and broke the chain leading to cell growth.
(...) new drugs might be developed that could specifically target cPLA2 and prevent COX2 from being released.
(...) "So if you can find a way to block that cascade in the tumor, starting with cPLA2, you might have a new way of modifying or slowing tumor growth."
(...) cPLA2 inhibitors would avoid the problems inherent in the class of drugs known as COX2 inhibitors. These drugs have been shown to be effective against tumor growth as well as in treating the pain associated with inflammatory conditions such as arthritis, but have been implicated in increased risk of cardiovascular problems in people who take them regularly.
Posted by Richard at September 2, 2005 12:53 PM
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