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July 20, 2005

Molecular Link Found Between Obesity And Diabetes

Topics: Medicine

Finding a protein that is released by fat tissue that causes insulin resistance, is a significant step forward in developing anti-diabetic therapies. Identifying a molecular link between obesity and type-2 diabetes opens the door for development of strategies for treating the disease at the source.

- Reuters

[...]They found that a protein released by fat tissue in mice causes insulin resistance, a primary risk factor for diabetes. Elevated levels of the protein had also previously been detected in patients suffering from diabetes.

"Being resistant to insulin is one of the major causes of diabetes," said Dr Barbara Kahn of Beth Israel Deaconess medical Center in Boston, Massachusetts, and the lead author of the research published in the science journal Nature.

"And in the absence of diabetes, insulin resistance is a major risk factor for heart disease and early mortality." Read more...

The scientists found that increasing levels of retinol binding protein (RBP4) caused insulin resistance while decreasing levels relieved the condition. This implicates RBP4 because it's known that the severity of insulin resistance in people who are obese or suffer from type 2 diabetes, have excess amounts of RBP4.

Posted by Hyscience at July 20, 2005 2:46 PM



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