April 6, 2005
Urine hyaluronidase RNA shows promise in detecting bladder carcinomaTopics: Medicine
Promising news on the possibility for early detection in bladder cancer.
According to an April 1 report in Cancer(via Reuters), urine levels of hyaluronidase RNA detect bladder carcinoma with greater sensitivity and specificity than other markers(Cancer 2005;103:1356-1362). When researchers compared the sensitivity and specificity for diagnosis of bladder carcinoma using hyaluronidase RNA in cellular pellet from voided urine samples with those of CK-20 RNA, hyaluronic acid, and urine cytology, hyaluronidase mRNA was detected in 90.8% of patients with malignant bladder tumors, 10.2% of those with benign bladder pathology, and none of those in the control group. CK-20 (cytokeratin 20) mRNA was detected in 78.1% of malignant cases and 2.9% of benign cases. False positive cytologic results were returned in 30.9% of benign cases, and it also had a lower sensitivity (68.9%) than the other two tests.
The researchers note that these results translate into overall sensitivity and specificity in diagnosing bladder carcinoma of 90.8% and 93.4% for hyaluronidase mRNA; substantially higher than the 85.8% and 60.7% for a hyaluronic acid level above 58.5 unit/mg protein. This high sensitivity is among the best reported using a single test," the investigators write.
The simultaneous use of telomerase, cytokeratin 20 and CD4 for bladder cancer detection in urine.
Quantitative detection of cytokeratin 20 mRNA expression in bladder carcinoma by real-time reverse transcriptase-polymerase chain reaction.
cross posted at NewHopeBlog
Posted by Hyscience at April 6, 2005 4:13 PM
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