« Exercise in Dhimmitude 101: Journalists Afraid To Criticize Islam? | Main | The Hospice Industry's Dark Agenda: Are Hospices Enabling Euthanasia? »
April 8, 2005
Report on Meta-analysis of "Effectiveness of anti-anemia drug in treatment of cancer patients"
Topics: Clinical PharmacologyIn a meta-analysis to determine the association between erythropoietin treatment and hematologic response, blood transfusions, adverse events, and overall survival, it has been found that erythropoietin treatment for anemia may reduce the risk for blood transfusions and improve hematologic response in cancer patients, but evidence that the treatment affects survival is inconclusive(meta-analysis of 27 randomized, controlled trials published between 1993 and May 2002. The trials had compared erythropoietin treatment versus no treatment in a total of 3,287 adult cancer patients).
(...) likelihood of needing a blood transfusion was lower in patients who received erythropoietin treatment than in those who did not. Erythropoietin-treated patients with very low baseline hemoglobin levels were more likely to have a hematologic response than untreated patients. The risk for thromboembolic events was similar in both groups.
(...) researchers also found suggestive but inconclusive evidence that erythropoietin may improve overall survival. However, this contrasts with the results of two recently published randomized controlled trials--which were not included in this analysis because they were published after the cutoff point for inclusion in the systematic review--in which patients treated with erythropoietin had worse survival than untreated patients.
(...) "In view of the inconclusive evidence presently available, our results suggest that erythropoietin should not be used to increase overall survival outside clinical trials,"
Read more ...
Journal Source
Related reading:
Effectiveness of erythropoietin in the treatment of patients with malignancies: methods and preliminary results of a Cochrane review.
The impact of anaemia on outcome in cancer.
Hypoxia and anemia: factors in decreased sensitivity to radiation therapy and chemotherapy?
Cross posted at NewHopeBlog
Posted by Hyscience at April 8, 2005 12:31 PM
Articles Related to Clinical Pharmacology:
- Britain tests first Cannabis related medicine for rheumatoid arthritis - Nov 13, 2005
- Experimental human monoclonal antibody shows striking benefit in patients with advanced melanoma - May 26, 2005
- Cystatin C May Push Creatinine Off Risk Radar - May 19, 2005
- Cancer Treatment Success Stuns Scientists - May 16, 2005
- Antibody, cancer drug combo shows promise against breast tumors - May 16, 2005
- USC researchers determine mechanism of action of motexafin gadolinium (Xcytrin) - May 02, 2005
- Herceptin® Combined With Chemotherapy Improves Disease-Free Survival for Patients With Early-Stage Breast Cancer - Apr 26, 2005
- Selenium will have critical role in prostate cancer treatment - Fox Chase Cancer Center - Apr 21, 2005
- Traditional Medicine Derivatives Kill Cancer Cells - Apr 20, 2005
- Compound from Chinese medicine shows promise in head and neck cancer, U-M study finds - Apr 19, 2005



















