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April 4, 2005

Drug to be tested for breast-cancer prevention

Topics: Clinical Pharmacology

In post-menopausal women, estrogen is no longer produced by the ovaries, but is converted from another hormone, called androgen. Aromatase inhibitors keep androgen from being converted to estrogen. That means less estrogen in the bloodstream, and less estrogen reaching estrogen receptors to trigger trouble.

According to an article in the March 31, 2005 GlobeandMail.com, breast-cancer researcher Dr. Paul Goss is seeking to answer the question of whether drugs called aromatase inhibitors have a role to play in disease prevention in women after they go through menopause - the time of life when three-quarters of breast cancers are diagnosed.

- GlogeAndMail.com
Researchers in Canada and the United States are embarking on a clinical trial to see if a drug that is highly effective in treating breast cancer could be used to prevent it.

(...) Currently, there is little that doctors can offer women who are at high risk of developing breast cancer, apart from the always sage advice to eat a healthy diet and exercise.

(...)  Half will receive exemestane and the other half will receive a placebo. Neither the women nor their doctors will know which participants are getting the drug. Treatment will continue for five years, and the women will be followed well after that, Dr. Goss said, to compare breast-cancer rates among those who took the drug and those who did not.

Read more ...

cross posted at NewHopeBlog

Posted by Hyscience at April 4, 2005 11:16 PM

I wonder whether time would be better spent researching breast cancer in women who have not reached menopause. The number of women in this category is continually rising. My late mother in law was amongst the women who have not reached menopause when she was diagnosed and subsequently died from this particular cancer.

For most of my life, I had been told that breast feeding was supposed to provide some form of protection against getting breast cancer. My late mother in law had 7 children and she breast fed all of them. In my mind that does not add up and there should be further research on the so called relationship between breast feeding and breast cancer.

Why did Faye get breast cancer? She also had several miscarriages. When a women becomes pregnant there is a change in various hormones in the body. Her endocrine system goes through a variety of changes as a result of the pregnancy. When a woman terminates her child, she is at risk of the hormones not returning to normal. I suspect that the miscarriages, with their changes in hormone levels is an influential factor with regard to her breast cancer.

It is true that at menopause there are other changes in the body, but we do not need extra doses of estrogen to cope with the menopause symptoms. This is something that has been sold to to the public and allows the pharmaceutical companies to push HRT.

One alternative to HRT is Livial. It als works on the brain. I have been using it for approximately one month because I was having the hot flushes (pretty hard to tell what is happening when it has been so hot). The Livial is also expected to affect the signals of the brain as the natural levels of estrogen and progesterone begin to drop.

Posted by: Maggie4life at April 5, 2005 12:50 AM



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