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March 10, 2005

Scientists have identified a key network that prevents damage by oxygen radicals

Topics: Medicine

Reactive oxygen species (ROS), or 'oxygen radicals', have been identified as major contributors to signs of premature aging, increased cancer prevalence linked to inflammation-associated syndromes and a variety of human diseases.

Scientists at the University of California, San Diego Branch of the Ludwig Institute for Cancer Research (LICR) have identified a key network of DNA repair and cell cycle control genes in yeast that prevents the deleterious effects of ROS.

(...)  "DNA repair and cell cycle control mechanisms are important guardians against cancerous changes in human cells," says Dr. Richard Kolodner, LICR Member and senior author of the study. "However, the effects of ROS on these cellular responses have not been well characterized. We've now identified a group of genes that cooperate to suppress DNA mutations and the genome rearrangements that are the hallmarks of cancer cells that occur in response to ROS."

(...) "These results suggest that endogenous ROS-induced genome instability may contribute to cancer progression," says Dr. Kolodner, professor of medicine with UCSD School of Medicine and member of the Rebecca and John Moores UCSD Cancer Center. "And increased ROS is almost certainly more harmful in cells with acquired mutations in other genes in the network. However the connections we've found might point to new strategies, like dietary supplements, that will alleviate some of the clinical symptoms of human diseases associated with genetic deficiencies of DNA damage responses."

Posted by Hyscience at March 10, 2005 10:12 PM

It is very true. Serial killers and Pedophiles are granted more liberties than Terri Schiavo. How can a judge live with himself knowing that he is basically irradicating an innocent human being?

Posted by: b at March 11, 2005 9:18 AM

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