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March 15, 2005

New Cancer Drug May Block Tumor Growth

Topics: Medicine

A new cancer drug may halt tumor growth by blocking the division of cancerous cells while leaving healthy cells alone, according to early tests in animals.

Researchers say if further studies confirm these results in humans, the experimental cancer drug may be a new way to offer highly targeted cancer treatment with few side effects.

The study suggests that the drug, known as ONO1910, works by zeroing in on a molecule called PLK1 that is known to play a critical role in the spread of cancer. The molecule drives normal cell division. High levels of it have been found in human cancer tumors and have been associated with more aggressive and deadly cancers.

Related reading:

Supplemental research data

The Plk3-Cdc25 circuit.

Interaction of chromatin-associated Plk1 and Mcm7.

Polo-like kinase 1 phosphorylates HSF1 and mediates its nuclear translocation during heat stress.

Polo-like kinases (Plks) and cancer.

Posted by Hyscience at March 15, 2005 3:15 PM

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