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February 15, 2005
Green Tea Extract Has Potential as Anti-Cancer Agent, According to UCLA Researchers
Topics: Clinical PharmacologyA study on bladder cancer cells lines showed that green tea extract has potential as an anti-cancer agent, proving for the first time that it is able to target cancer cells while leaving healthy cells alone.
The study, published in the Feb. 15, 2005 issue of the peer-reviewed journal Clinical Cancer Research, also uncovered more about how green tea extract works to counteract the development of cancer, said JianYu Rao, a Jonsson Cancer Center member, an associate professor of pathology and laboratory medicine and the study's senior author.
"Our study adds a new dimension in understanding the mechanisms of green tea extract," Rao said. "If we knew exactly how it works to inhibit the development of cancer, we could figure out more precisely which bladder cancer patients might benefit from taking it."
... Numerous epidemiologic and animal studies have suggested that green tea extract provides strong anti-cancer effects in several human cancers, including bladder cancer. It has been shown to induce death in cancer cells, as well as inhibiting the development of an independent blood supply that cancers develop so they can grow and spread.
... "In effect, the green tea extract may keep the cancer cells confined and localized, where they are easier to treat and the prognosis is better," Rao said. " Cancer cells are invasive and green tea extract interrupts the invasive process of the cancer."
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Epigallocatechin-3-gallate induces mitochondrial membrane depolarization and caspase-dependent apoptosis in pancreatic cancer cells.
In vivo antitumor effect of ascorbic acid, lysine, proline and green tea extract on human colon cancer cell HCT 116 xenografts in nude mice: Evaluation of tumor growth and immunohistochemistry.
Molecular and cellular effects of green tea on oral cells of smokers: a pilot study.
Bioavailability and antioxidant activity of tea flavanols after consumption of green tea, black tea, or a green tea extract supplement.
Posted by Hyscience at February 15, 2005 8:19 PM
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