« Iran Says It Will Never Abandon Nuclear Program | Main | Trouble-Speak in Colorado: Is prof under fire really an Indian? »
February 3, 2005
Death by Enema
Topics: Strange but trueTammy Jean Warner, 42, is accused of negligent homicide in the death of her husband Michael Warner, 58, who died with an alcohol level of 0.47%. Michael Warner, a long time alcoholic, could no longer drink due to a throat condition. Mrs. Warner is accused of causing his death by giving Mr. Warner a 3-liter sherry enema in order for him to get intoxicated. He was later found dead in his bed.
Obviously, Tammy Jean would have failed a test in basic pharmacokinetics. Before any readers attempt Tammy's method of alcohol administration, they should take a look at a comparative analysis of the differences in intravenous, oral, colon, and rectal administration of solutions.
In the study refered to here, absolute bioavailability after the oral dosing, colonic infusion, and rectal administration averaged 71 +/- 14, 74 +/- 26, and 58 +/- 18%, respectively. These values were not significantly different (P > 0.05). Values of Tmax and Cmax were also not significantly different among the nonparenteral routes. Mean absorption half-lives were 0.66, 1.1, and 0.75 hr after the oral, colonic, and rectal administrations, respectively.
In the future I would recommend that Tammy and all copycats take this data into consideration when arriving at the dosage and route of administration they intend to use, regardless of the drug. Furthermore, if a quality wine is the drug of choice, the rectal route of administration is a poor selection, regardless of one's taste or sexual inclination!
Hat tip - Digger's Realm
Posted by Hyscience at February 3, 2005 1:13 PM
Hahaha! I didn't understand a word of your analysis between the methods of introduction into the system, but I assume you are saying that rectal administration is more quickly distributed into the system than oral.
I take it that not having gone through the stomach acids also was a factor in the quantity of alcohol introduced into his system.
Posted by: Digger at February 3, 2005 3:12 PM
Articles Related to Strange but true:
- Death by Enema - Feb 03, 2005
