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February 4, 2005

Clonally expanded novel multipotent stem cells from human bone marrow regenerate myocardium after myocardial infarction.

Topics: Medicine

Adult subpopulation of stem cells could have function similar to embryonic stem cells

The researchers have made a discovery that could revolutionize the stem cell research debate. They believe they have discovered an adult stem cell that has the same potential as embryonic stem cells.

I think embryonic stem cells are going to fade in the rearview mirror of adult stem cells, Losordo said, according to the Washington newspaper.

- J Clin Invest. 2005 Feb 1;115(2):326-338.
Researchers have identified a subpopulation of stem cells within adult human bone marrow (BM), isolated at the single-cell level, that self-renew without loss of multipotency for more than 140 population doublings and exhibit the capacity for differentiation into cells of all 3 germ layers.

Based on surface marker expression, these clonally expanded human BM-derived multipotent stem cells (hBMSCs) do not appear to belong to any previously described BM-derived stem cell population. Intramyocardial transplantation of hBMSCs after myocardial infarction resulted in robust engraftment of transplanted cells, which exhibited colocalization with markers of cardiomyocyte (CMC), EC, and smooth muscle cell (SMC) identity, consistent with differentiation of hBMSCs into multiple lineages in vivo. Furthermore, upregulation of paracrine factors including angiogenic cytokines and antiapoptotic factors, and proliferation of host ECs and CMCs, were observed in the hBMSC-transplanted hearts. Coculture of hBMSCs with CMCs, ECs, or SMCs revealed that phenotypic changes of hBMSCs result from both differentiation and fusion. Collectively, the favorable effect of hBMSC transplantation after myocardial infarction appears to be due to augmentation of proliferation and preservation of host myocardial tissues as well as differentiation of hBMSCs for tissue regeneration and repair. To the researcher's knowledge, this is the first demonstration that a specific population of multipotent human BM-derived stem cells can induce both therapeutic neovascularization and endogenous and exogenous cardiomyogenesis.

Posted by Hyscience at February 4, 2005 7:50 PM



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