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December 22, 2004
Naproxen in the firing line!
Topics: Clinical PharmacologyQuick Clinpharm Update:
The
US NIH has announced that it is suspending a large clinical trial
studying the effects of long term NSAID in the prevention of
Alzheimer's disease (AD).
This trial aimed to determine whether
naproxen or celecoxib reduced the risk for development of AD and was
intended to run for three years. Two reasons have been given for the
suspension of the trial - the first was the increased risk of
cardiovascular events with celecoxib in another trial, announced last
Friday and reported here;
the second was an apparent increase in the incidence of 'cardiovascular
and cerebrovascular events' in the patients taking naproxen. There are
no further details available at the moment: the FDA is advising people
taking OTC naproxen to follow the directions on the label, and those
taking prescribed naproxen who have concerns to contact their doctor.
[Editor's comment: at the moment, patients can be reassured that this
does not prove naproxen to be unsafe - other work suggests a protective
effect with naproxen, as reported here and here. More information is required before any specific decision can be taken.] Source...
Posted by Hyscience at December 22, 2004 6:56 PM
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