« Naproxen in the firing line! | Main | Will Christian Resistance Rally in the War on Christmas? »

December 22, 2004

Early research - taxanes for Alzheimer's?

Topics: Clinical Pharmacology

Quick Clinpharm Update:

Preclinical animal work suggests that paclitaxel may have beneficial effects in Alzheimer's disease (AD).

The research used mice bred to develop an AD-like condition with pathological effects similar to those of AD. They were given paclitaxel once a week in two different doses for twelve weeks. Compared to untreated animals, those receiving paclitaxel showed less impairment of neuronal function and reduced disease symptoms. The authors suggest that it may be possible to move quickly to clinical trials because drugs of this type are already established in therapy, however it will be necessary to develop molecules that cross the blood-brain barrier effectively.  Source...

Posted by Hyscience at December 22, 2004 7:07 PM

Articles Related to Clinical Pharmacology:

• Britain tests first Cannabis related medicine for rheumatoid arthritis - Nov 13, 2005
• Experimental human monoclonal antibody shows striking benefit in patients with advanced melanoma - May 26, 2005
• Cystatin C May Push Creatinine Off Risk Radar - May 19, 2005
• Cancer Treatment Success Stuns Scientists - May 16, 2005
• Antibody, cancer drug combo shows promise against breast tumors - May 16, 2005
• USC researchers determine mechanism of action of motexafin gadolinium (Xcytrin) - May 02, 2005
• Herceptin® Combined With Chemotherapy Improves Disease-Free Survival for Patients With Early-Stage Breast Cancer - Apr 26, 2005
• Selenium will have critical role in prostate cancer treatment - Fox Chase Cancer Center - Apr 21, 2005
• Traditional Medicine Derivatives Kill Cancer Cells - Apr 20, 2005
• Compound from Chinese medicine shows promise in head and neck cancer, U-M study finds - Apr 19, 2005