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December 22, 2004
Early research - taxanes for Alzheimer's?
Topics: Clinical PharmacologyQuick Clinpharm Update:
Preclinical
animal work suggests that paclitaxel may have beneficial effects in
Alzheimer's disease (AD).
The research used mice bred to develop an
AD-like condition with pathological effects similar to those of AD.
They were given paclitaxel once a week in two different doses for
twelve weeks. Compared to untreated animals, those receiving paclitaxel
showed less impairment of neuronal function and reduced disease
symptoms. The authors suggest that it may be possible to move quickly
to clinical trials because drugs of this type are already established
in therapy, however it will be necessary to develop molecules that
cross the blood-brain barrier effectively. Source...
Posted by Hyscience at December 22, 2004 7:07 PM
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- Early research - taxanes for Alzheimer's? - Dec 22, 2004
