« Pfizer Statement Regarding Additional Prescribing Information for Depo-Provera | Main | Moderate Muslims and Arabs Emerge from the Shadows, Or, Maybe Not »

November 21, 2004

Potential drug interaction with paclitaxel and highly active antiretroviral therapy in two patients with AIDS-associated Kaposi sarcoma.

Topics: Clinical Pharmacology

Abstract Review:
Am J Clin Oncol. 2004 Feb;27(1):81-4. Bundow D, Aboulafia DM., Virginia Mason Medical Center, Seattle, Washington, USA:

Highly active antiretroviral therapy (HAART) consisting of multiple combinations of antiretroviral agents that inhibit HIV (HIV) replication has been associated with improvements in CD4+ T-lymphocyte cell counts, suppression of HIV replication, and regression of HIV-associated Kaposi's sarcoma (KS). Several of these agents have complex drug-drug interactions and have the potential to aggravate paclitaxel-associated toxicities. Herein two patients with KS are described who received paclitaxel while on HAART and who developed life-threatening toxicities. These cases are presented to alert clinicians to potentially serious drug interactions that can occur between various components of HAART and paclitaxel. Clinicians contemplating taxane-based chemotherapy for HIV-associated KS should carefully monitor patients for adverse events and, depending on their patient's HAART regimen, consider reducing the taxane dose.  Source - PMID: 14758138

Posted by Hyscience at November 21, 2004 9:26 PM

Articles Related to Clinical Pharmacology:

• Britain tests first Cannabis related medicine for rheumatoid arthritis - Nov 13, 2005
• Experimental human monoclonal antibody shows striking benefit in patients with advanced melanoma - May 26, 2005
• Cystatin C May Push Creatinine Off Risk Radar - May 19, 2005
• Cancer Treatment Success Stuns Scientists - May 16, 2005
• Antibody, cancer drug combo shows promise against breast tumors - May 16, 2005
• USC researchers determine mechanism of action of motexafin gadolinium (Xcytrin) - May 02, 2005
• Herceptin® Combined With Chemotherapy Improves Disease-Free Survival for Patients With Early-Stage Breast Cancer - Apr 26, 2005
• Selenium will have critical role in prostate cancer treatment - Fox Chase Cancer Center - Apr 21, 2005
• Traditional Medicine Derivatives Kill Cancer Cells - Apr 20, 2005
• Compound from Chinese medicine shows promise in head and neck cancer, U-M study finds - Apr 19, 2005